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Hydrogels for Osteochondral
Tissue Engineering
Journal of Biomedical

(March 2020)
Anti-Wrinkle Activity
& Transdermal Delivery
of GHK Peptide
Journal of Peptide Science
(March 2020)
Pulsed Glow Discharge
to GHK-Cu Determination
International Journal
of Mass Spectrometry

(March 2020)
Protective Effects of GHK-Cu
in Pulmonary Fibrosis
Life Sciences
(January 2020)
Anti-Wrinkle Benefits
of GHK-Cu Stimulating
Skin Basement Membrane
International Journal of Molecular Sciences
(January 2020)
Structural Analysis
Molecular Dynamics of
Skin Protective
TriPeptide GHK
Journal of Molecular Structure
(January 2020)
In Vitro / In Vivo Studies
pH-sensitive GHK-Cu in
Superabsorbent Polymer
GHK Enhances
Stem Cells Osteogenesis
Acta Biomaterialia
Antibacterial GHK-Cu
Nanoparticles for
Wound Healing
Particle & Particle (2019)
Effect of GHK-Cu
on Stem Cells and
Relevant Genes
OBM Geriatrics
GHK Alleviates
Neuronal Apoptosis Due
to Brain Hemorrhage
Frontiers in Neuroscience
Endogenous Antioxidant
International Journal of Pathophysiology and Pharmacology (2018)
Regenerative and
Protective Actions of
GHK-Cu Peptide
International Journal of
Molecular Sciences
Skin Regenerative and
Anti-Cancer Actions
of Copper Peptides
GHK-Cu Accelerates
Scald Wound Healing
Promoting Angiogenesis
Wound Repair and

GHK Peptide Inhibits
Pulmonary Fibrosis
by Suppressing TGF-β1
Frontiers in Pharmacology
Skin Cancer Therapy
with Copper Peptides
The Effect of Human
Peptide GHK Relevant to
Nervous System Function
and Cognitive Decline
Brain Sciences (2017)
Effects of Tripeptide
GHK in Pain-Induced
Aggressive Behavior
Bulletin of Experimental
Biology & Medicine
GHK-Cu Elicits
In Vitro Alterations
in Extracellular Matrix
Am Journal of Respiratory
and Critical Care Medicine

Selected Biomarkers &
Copper Compounds
Scientific Reports

GHK-Cu on Collagen,
Elastin, and Facial Wrinkles
Journal of Aging Science
Tri-Peptide GHK-Cu
and Acute Lung Injury

Effect of GHK Peptide
on Pain Sensitivity
Experimental Pharmacology

New Data of the
Cosmeceutical and
TriPeptide GHK
SOFW Journal
GHK Peptide as a
Natural Modulator of
Multiple Cellular Pathways
in Skin Regeneration
BioMed Research (2015)
Resetting Skin Genome
Back to Health
Naturally with GHK
Textbook of Aging Skin
GHK-Cu May Prevent
Oxidative Stress in Skin
by Regulating Copper and
Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK Increases
TGF-β1 in
Human Fibroblasts

Acta Poloniae

The Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology
Resetting the
Human Genome to Health
BioMed Research
Enhanced Tropic Factor Secretion of Mesenchymal
Stem Cells with GHK
Acta Biomater
Anxiolytic (Anti-Anxiety)
Effects of GHK Peptide
Bulletin of Experimental
Biology & Medicine
Lung Destruction and
its Reversal by GHK
Genome Medicine
TriPeptide GHK Induces
Programmed Cell Death
of Neuroblastoma
Journal of Biotechnology
Stem Cell
Recovering Effect
of GHK in Skin
Peptide Science
Skin Penetration of
Copper Tripeptide in Vitro
Journal of International
Inflammation Research
Possible Therapeutics
for Colorectal Cancer
Journal of Clinical and
Experimental Metastasis
Methods of Controlling
Differentiation and
Proliferation of Stem Cells
Effects of
Copper Tripeptide
on Irradiated Fibroblasts
American Medical Association
Avoid Buying Fake Copper Peptides Dangerous

What Happens to Your Skin as You Get Older?

As your body ages, the appearance and characteristics of your skin change. Visible aging of your skin starts around age 25 as your natural regenerative processes begin to slow.

Your skin replaces old cells more slowly and there is a slower turnover of the surface skin as well as slower wound healing.

Around age 45, the skin begins to thin, due in part, to hormonal changes. This thinning makes your skin more fragile and vulnerable to damage by abrasion and more sensitive to irritating environmental factors and allergens.

The coils of collagen and elastin in your skin suffer cuts and cross linking damage and as a result, the skin loses much of its strength and elasticity. The moisture holding proteoglycans and glycosaminoglycans decrease in abundance, making the skin become dryer and looser.

Your skin loses fat, so it looks less plump and smooth. The number of blood vessels in your skin decreases, and the skin loses its youthful color and glow.




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This can be seen as four basic changes:

Change 1 The rate of the skin cell replacement decreases, producing a thinner, more fragile skin. Skin is replaced every three weeks at age 20 but this slows to every nine weeks by age 50.

Change 2 Damaged proteins accumulate in the skin. This damage can be the result of scars, sun damage, oxidative damage, and the cross-linking of skin proteins by sugars.

Change 3 Around age 25, skin oil production starts to drop. This reduces acne but produces a dryer skin. This drop in oil production becomes more serious after age 45.

Change 4 The biosynthesis and breakdown of collagen, elastin, and water-holding glycosaminoglycans exists in a dynamic balance in young healthy skin. However after age 25, the skin's production of collagen, elastin, and the water-holding GAGs slows down while the rate of breakdown of these factors speeds up, thus starting the beginning of wrinkle formation and loss of elasticity. This problem becomes progressively more serious with passing years.

While all these changes are taking place, gravity is also at work, pulling at your skin, causing it to sag.

Wrinkles around the eyes are a characteristic signs of skin damage. Your skin tends to heal more slowly and minor blemishes develop.

In addition, this aging process can be exacerbated by factors such as extremes of cold or heat, excessive sunlight exposure (UV radiation), psychological stress, and improper nutrition.

The effects of this photodamage can be seen by comparing the skin of people living in sunny locales to those in hady regions. Exposed skin shows mottled hyperpigmentation while the non exposed skin is usually clearer and paler.

Older Woman in a Rocking Chair

Your Daily Routine Could Lead to Dry Skin

During aging the oil-producing (sebaceous) glands become less active, and your skin becomes drier.

The skin becomes more sensitive to the use of harsh soaps and disinfectants which more easily damage skin.

You have a natural oil covering your skin called sebum, which is produced by glands in the skin.

Frequent use of drying agents, such as soap, remove this oil and causes your skin to become dry, which can lead to cracking and flaking. Once your skin begins to crack, it becomes susceptible to inflammation and itching.

Everyday factors that may cause your skin to crack include harsh soaps or long hot baths and showers. In our modern culture, most people overdo skin cleansing to the point of damage.

Skin Layers