Search Skin Biology
| Study | Result | References |
Methods to Reverse Aging Effects in Human Skin |
Several open studies gave evidence for wrinkle reduction, blemish reduction, increased skin thickness, elasticity, and improved appearance. | Pickart US Patents, 5,135,913 Skin treatment composition comprises GHL-CU or derivatives for improving skin health, increasing subcutaneous fat, dermal thickness and density, 5,348,943 Cosmetic and skin treatment compositions. |
Human Skin Renewal Study |
A clinical study which compared the effect on the skin's production of collagen after using creams containing copper-peptides, vitamin C, or retinoic acid (retin-A) Twenty volunteers applied the various creams to their thighs daily for one month. New collagen production was determined by studying skin biopsy samples using immunohistological techniques. |
Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study. Abdulghani A.A.; Sherr A.; Shirin S.; Solodkina G.; Tapia E.M.; Wolf.GottliebA.B.; Dermatology, UMDNJ, Robert Wood Johnson Medical School; Disease Management and Clinical Outcomes, 1998, 1:136-141. |
Human Skin Renewal Study |
GHK-Cu containing liquid foundation tested on skin appearance, skin elasticity and epidermal thickness in an 8 week study. GHK-Cu containing liquid foundation improved skin appearance, and increased skin elasticity and epidermal thickness. | A Clinical Evaluation of a Copper-Peptide Containing Liquid Foundation and Cream Concealer Designed for Improving Skin Condition. Appa Y, Barkovic S, Finkey M B, Neutrogena Corporation, Los Angeles, CA, Stephens, T, TJ Stephens & Associates, Inc, Dallas, TX Abstract P66, American Academy of Dermatology Meeting, February 2002 |
Reduction of Photo Damage |
GHK-Cu containing creams tested for reducing visible signs of aging and increasing skin density. GHK-Cu containing creams reduced visible signs of aging and increased skin density in 8 weeks on facial skin. | The Effect of Tripeptide to Copper Ratio in Two Copper Peptide Creams on Photoaged Facial Skin. Leyden J, University of Pennsylvania, Philadelphia, PA, Grove, G, KGL, Inc/Skin Study Center, Broomall, PA; Barkovic S, Appa Y, Neutrogena Corporation, Los Angeles, CA; Abstract P67, American Academy of Dermatology Meeting, February 2002 |
Human Skin Renewal Study |
GHK-Cu containing creams tested for effect on wrinkles, fine line, skin elasticity, skin density, and thickness. Placebo-controlled study, 71 females, 12 weeks. GHK-Cu containing creams reduced wrinkles and fine lines while increasing skin elasticity, skin density, and thickness. | Skin Care Benefits of Copper Peptide Containing Facial Cream. Leyden J, University of Pennsylvania, Philadelphia, PA Stephens T, Thomas J Stephens & Associates, Inc, Dallas, TX; Finkey MB, Barkovic S, Neutrogena Corporation, Los Angeles, CA; Abstract P68, American Academy of Dermatology Meeting, February 2002 |
Human Skin Renewal Study |
GHK-Cu containing eye creams tested on wrinkles, fine lines and eye appearance in placebo controlled study, 41 females, 12 weeks. In a second placebo controlled, 3 week, half face study, GHK-Cu was significantly better than a vitamin K cream.
GHK-Cu containing eye creams reduced wrinkles and fine lines while improving eye appearance in placebo-controlled study. GHK-Cu was significantly better than a vitamin K cream. |
Skin Care Benefits of Copper Peptide Containing Eye Creams. Leyden J, University of Pennsylvania, Philadelphia, PA; Stephens T, Thomas J Stephens & Associates, Inc, Dallas, TX; Finkey MB, Barkovic S, Neutrogena Corporation, Los Angeles, CA; Abstract P69, American Academy of Dermatology Meeting, February 2002 |
Review |
Review of skin remodeling | Pickart L, Copper Peptides for Tissue Regeneration, Specialty Chemicals, Oct. 9, 2002, 29-31. 2002 |
Human Skin Renewal Study |
Renewal with GHK-Cu in SPF 20 skin cream | Stephens TJ, Sigler ML, Finkley MB, Appa Y, Skin benefits of a SPF-20 copper peptide containing skin cream, 61th Amer Acad Derm Meeting, San Francisco, 2003 |
Review |
Review of skin remodeling | Pickart L, Copper peptides for aging reversal, Body Language Dermatology, April 2003, |
Review |
Review of skin remodeling | Pickart, L, Copperceuticals and the skin, Cosmetics & Toiletries 2003, 118:24-28 |
Theory of Skin Remodeling |
Biochemical theory of mechanism of skin remodeling | Pickart L, Skin remodeling copper peptides, Cosmetics & Medicine (Russia) 2004, Number 2, pages 14-29, |
Review of Cosmetic Studies on GHK-Cu |
A series of placebo-controlled studies found GHK-Cu skin creams to: |
Copper Peptide and Skin, M.B. Finkley, Y. Appa, S. Bhandarkar, Cosmeceuticals and Active Cosmetic, 2nd Edition (ISBN: 0-8247-4239-7), 2005, pp 549-563 |
GHK actions on sebum production |
GHK suppresses sebum production in cultured sebocytes but not overall lipid synthesis | Schagen S, Voegeli R, Imfeld D, Schreier T, Zouboulis CC, Lipid regulation in SZ95 sebocytes by glycyl-histidyl-lysine, 16th European Academy of Dermatology and Venereology Congress, 16-20 May 2007 |
Review of Remodeling |
Review of the New Biochemistry and Cell Biology of Skin Remodeling | Pickart L, The human tripeptide GHK and tissue remodeling, "Wound Healing and Technology", J. Biomater, Sci. Polymer Edit. Vol 19, No. 8 pp. 969-988 (2008). |
Skin Penetration of Copper Peptides |
GHK-Cu penetrates skin via the horny lipid layer of the skin barrier | Mazurowska L, Mojski M, Biological activities of selected peptides: skin penetration ability of copper complexes with peptides, J Cosmet Sci. 2008 Jan-Feb;59(1):59-69. |
Update on Remodeling |
Presented at Wound Healing Society, April 2008 | Pickart L and Pickart F, GHK defines the biochemical reactions of tissue remodeling. Look at http://www.skinbiology.com/copperpeptideregeneration-WHS2008.html |
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